Thermo Fisher Scientific Granzyme K Monoclonal Antibody (2F9C12)
인간 Granzyme K 단백질을 인식하는 마우스 단클론 항체. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Protein G로 정제된 1 mg/mL 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | — |
| Flow Cytometry (Flow) | Assay-dependent | — |
| ELISA | 1:10,000 | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F9C12 |
| Immunogen | Purified recombinant fragment of human GZMK (AA: 27–264) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091009 |
Target Information
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localized in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11–12, close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specificity, cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen, and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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