Thermo Fisher Scientific ITM2B Polyclonal Antibody
ITM2B 단백질을 인식하는 Goat Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry 등에 사용 가능. Human에 반응하며, BSA 포함 TBS buffer에 보관. Alzheimer 및 신경퇴행성 질환 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HDKETYKLQRRETIK) corresponding to the internal amino acids of ITM2B (aa 224–239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985460 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, and rat based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides, which form the characteristic plaques of Alzheimer’s disease.
The ITM2B gene encodes a transmembrane protein processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations extending the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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