Thermo Fisher Scientific Podoplanin (PDPN) (Lymphatic Endothelial and Mesothelial Marker) Recombinant Rabbit Monoclonal Antibody (PDPN/7808R)
Podoplanin(PDPN) 단백질을 인식하는 재조합 토끼 단일클론 항체로, 림프관 내피 및 중피 표지에 적합합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Human 시료에 반응합니다. 4°C 보관, 동결 금지. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDPN/7808R |
| Immunogen | Recombinant fragment (around aa1–100) of human PDPN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly in lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.
As a regulator of the lymphatic endothelium, podoplanin contributes to maintaining podocyte morphology and serves as a ligand for CLEC-2. Its expression correlates with tumor invasiveness and metastatic potential. Podoplanin is involved in cell migration, metastasis formation, and tumor cell invasion. It is also induced via Src activation of Cas and has been detected on Th17 cells and a small subset of CD4+ PBMCs. Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottic neoplasm, and it has been proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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