Thermo Fisher Scientific Podoplanin (PDPN) (Lymphatic Endothelial and Mesothelial Marker) Recombinant Rabbit Monoclonal Antibody (PDPN/4009R)
인간 PDPN을 인식하는 재조합 토끼 단클론 항체로, 림프관 내피 및 중피세포 마커 연구에 적합합니다. IHC, ICC, ELISA 등 다양한 응용 가능하며, 고순도 Protein A/G 정제 및 PBS 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- 10630RBM2P1ABX
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Thermo Fisher Scientific Podoplanin (PDPN) Recombinant Rabbit Monoclonal Antibody (PDPN/4009R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDPN/4009R |
| Immunogen | Recombinant fragment (around aa1–100) of human PDPN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Podoplanin (PDPN, also known as T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of approximately 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic endothelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissues and thymic epithelial cells. As a regulator of lymphatic endothelium, it contributes to maintaining the unique shape of podocytes.
Podoplanin serves as a ligand for CLEC-2, and its expression correlates with higher invasive and metastatic potential in tumors. It is directly involved in cell migration, metastasis formation, and tumor cell invasion. Podoplanin expression can be induced via Src activation of Cas and has been detected on Th17 cells. Studies have shown its presence on a small but distinct population of CD4+ cells from human PBMCs. Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottic neoplasm. It is also proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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