Thermo Fisher Scientific TP53RK Monoclonal Antibody (2A9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

2A9

Immunogen

TP53RK (AAH09727, 154 a.a. approximately 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PRPK,uniProtId:Q96S44-1,ncbiNodeId:9606,antigenRange:154-253,antigenLength:253,antigenImageFileName:H00112858-M02A_PRPK_Q96S44-1_House_mouse.svg,antigenImageFileNamePDP:H00112858-M02A_PRPK_Q96S44-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: HDEDLIHGDL TTSNMLLKPP LEQLNIVLID FGLSFISALP EDKGVDLYVL EKAFLSTHPN TETVFEAFLK SYSTSSKKAR PVLKKLDEVR LRGRKRSMVG

Target Information

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates Ser-15 of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.