Thermo Fisher Scientific LATS2 Recombinant Rabbit Monoclonal Antibody (17H14L2)

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 1:100

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, Rat, and Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

Target Information

LATS2 (Large Tumor Suppressor Kinase 2) is a serine/threonine protein kinase belonging to the LATS tumor suppressor family.
It interacts with a negative regulator of p53 and functions in a positive feedback loop with p53 responding to cytoskeleton damage, leading to centrosome and mitotic apparatus regulation.

Biological Roles:

• Maintains mitotic fidelity and genomic integrity
• Regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis
• Functions in a kinase cascade with STK3/MST2 and STK4/MST1 that phosphorylates and activates LATS1/2
• Phosphorylates and inactivates YAP1 and WWTR1/TAZ, inhibiting nuclear translocation and regulating genes involved in proliferation, apoptosis, and migration
• Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.