Thermo Fisher Scientific DLL3 Recombinant Rabbit Monoclonal Antibody (7H24L4)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Not specified
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Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100
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Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, Pig, and Bovine.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The specific antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Protein: Delta-like protein 3 (DLL3)
Function: Ligand for the Notch signaling pathway; inhibits primary neurogenesis; involved in somite boundary formation during segmentation of the paraxial mesoderm.
Clinical relevance:
Defects in DLL3 cause Spondylocostal dysostosis autosomal recessive type 1 (SCDO1), leading to truncal shortening, abnormal spinal curvature, and sometimes a plagiocephaly-torticollis sequence. DLL3 may also play a role in directing neuronal differentiation pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.