Thermo Fisher Scientific WRNIP1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging, caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The WRNIP1 protein interacts with the exonuclease-containing N-terminal portion of the Werner protein and contains a ubiquitin-binding zinc-finger domain, ATPase domain, and two leucine zipper motifs. It shares sequence similarity with replication factor C family proteins and is conserved from E. coli to human. WRNIP1 likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins and binds to DNA polymerase delta to increase initiation frequency of DNA synthesis. It also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.