Thermo Fisher Scientific WRNIP1 Polyclonal Antibody
WRNIP1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 인간을 비롯해 마우스와 랫트에도 반응 예측됩니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 4°C에서 보관합니다.
- 카탈로그번호
- A301389AT
- 판매단위
- pk
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Thermo Fisher Scientific WRNIP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 450 of Human Werner helicase interacting protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
Werner’s syndrome is a rare autosomal recessive disorder characterized by accelerated aging caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein.
This protein has:
- A ubiquitin-binding zinc-finger domain in the N-terminus
- An ATPase domain
- Two leucine zipper motifs in the C-terminus
It shows sequence similarity to replication factor C family proteins and is conserved from E. coli to human. WRNIP1 likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins and binds to DNA polymerase delta, increasing initiation frequency of DNA synthesis. It also interacts with nucleoporins at nuclear pore complexes.
Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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