Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (MEM-75), Biotin
인간 CD71(Transferrin Receptor)에 특이적인 MEM-75 클론 단일클론 항체로, Biotin으로 표지됨. ICC/IF, Flow Cytometry, IP 등에 사용 가능. 액상 형태로 1 mg/mL 농도, 4°C 보관. 세포 내 철 수송 연구 및 면역분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 2–5 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-75 |
| Immunogen | Pre-B cell line NALM-6 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073337 |
Available Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages, and erythroid precursors. It is lost on resting blood leukocytes.
The MEM-75 antibody does not block binding of transferrin to its receptor.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release, and the apotransferrin-receptor complex is recycled to the cell surface.
Transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) serves as a diagnostic marker for various anemias and as a means of detecting erythropoietin (EPO) misuse in athletes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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