Thermo Fisher Scientific ESRRB Polyclonal Antibody
ESRRB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC(P), Flow Cytometry에 사용 가능. 인간 시료 반응성, 2 mg/mL 농도의 액상 형태. 자가 재생 및 줄기세포 유지 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 275–305 of human ESRRB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543570 |
Target Information
ESRRB (steroid hormone receptor ERR2) plays a key role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through signaling pathways such as FGF and Wnt. Upon FGF pathway activation, ESRRB interacts with KDM1A, binding directly to enhancer sites of ELF5 and EOMES to activate transcription, promoting trophoblast stem cell self-renewal. ESRRB also regulates expression of multiple rod-specific genes and is essential for their survival. Mutations in this gene can cause autosomal recessive deafness (DFNB35).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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