Thermo Fisher Scientific Neuropilin 1 Polyclonal Antibody
Neuropilin 1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow Cytometry에 사용 가능. 인간 반응성, 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
- 카탈로그번호
- PA526079
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 722–750 amino acids from the C-terminal region of human NRP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543579 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin 1 forms heterodimers with Neuropilin 2 (NRP2) and interacts with plexin (PLXNB1) to form semaphorin receptors. Predominantly expressed in the nervous system, it plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis outside the nervous system. It functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis. Neuropilin 1 may be involved in advanced prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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