Thermo Fisher Scientific HIV1 Tat Monoclonal Antibody (7)
HIV-1 Tat 단백질을 인식하는 Mouse monoclonal 항체로, Western blot, ELISA, ChIP 등 다양한 응용에 적합합니다. HIV-1 Tat BH10 및 IIIB 균주에 반응하며, Protein G 정제, PBS buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA171509
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 3 publications |
| ELISA | 0.2–1 µg/mL | – |
| Immunoprecipitation (IP) | – | View 1 publication |
| ChIP assay (ChIP) | 1–3 µL | – |
| In vitro Assay (IV) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Virus |
| Published Species | Virus |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7 |
| Immunogen | Recombinant Tat protein of HIV-1 BH10 purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_962124 |
Product Specific Information
This antibody reacts with HIV-1 Tat BH10 and IIIB strains. It also recognizes rTat consensus sequences of HIV-1 subtypes A (PNLEPWH), B (PRLEPWK), and C (PNLEPWN), mapped to amino acids 6–12 (PRLEPWK, B subtype consensus).
MA1-71509 is suitable for chromatin immunoprecipitation (ChIP) analysis of HIV-1 Tat.
This clone may also be referred to as 7 (02-002).
Target Information
HIV-1 Tat (Trans-Activator of Transcription) consists of 86–101 amino acids depending on the subtype. Tat plays a crucial role in HIV replication by compensating for transcriptional defects in the viral genome. It binds and phosphorylates cellular factors, overcoming RNA hairpin structures to promote efficient transcription of HIV RNA, establishing a positive feedback loop. Tat protein is secreted by infected cells and detectable in the blood of HIV-1 infected patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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