Thermo Fisher Scientific Human Serpin C1 Native Protein

Applications

• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-43136 contains native human Antithrombin III protein.
RP-43136 may be used as a positive control in many immunological assays.
The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process and found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore, and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.

Target Information

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. It inhibits thrombin and other activated serine proteases of the coagulation system, regulating the blood coagulation cascade.
The protein includes two functional domains: the heparin-binding domain at the N-terminus and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin.
More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.