Thermo Fisher Scientific BACE2 Polyclonal Antibody
인간 및 생쥐 BACE2 단백질을 검출하는 Rabbit Polyclonal 항체로 Western blot 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. PBS/BSA 완충액에 보관하며 알츠하이머 연구에 유용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:10–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C P(503) E V V N D E S S L V R H R W K(518) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_326006 |
Product Specific Information
PA1-754 detects human and mouse beta-secretase 2 (BACE2) from transfected cells.
This product has been remanufactured in new rabbits as Cat. # PA1-1754.
PA1-754 has been successfully used in Western blot and ICC/IF procedures.
In Western blot, this antibody detects an ~58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene.
The PA1-754 immunogen corresponds to amino acid residues 503–518 from human BACE2, which is completely conserved in mouse.
The PA1-754 immunizing peptide (Cat. # PEP-167) is available for use in neutralization and control experiments.
Target Information
BACE2 (Beta Secretase 2) is responsible for proteolytic processing of the amyloid precursor protein (APP).
BACE2 cleaves APP between residues 690 and 691, leading to generation and extracellular release of beta-cleaved soluble APP.
It can also cleave APP between residues 671 and 672.
Accumulation of APP is a hallmark of Alzheimer’s disease and a common complication in adult Down syndrome patients.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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