Thermo Fisher Scientific ARHGAP24 Polyclonal Antibody
ARHGAP24 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 응용 가능. Human, Mouse, Rat 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 세포 극성 및 형태 조절 연구에 적합.
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- PA5104104
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human ARHGAP24 (Accession Q8N264), amino acid residues S573–A623 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853432 |
Product Specific Information
Antibody detects endogenous levels of total RHG24.
Target Information
Rho GTPase-activating protein involved in cell polarity, morphology, and cytoskeletal organization. Acts as a GTPase activator for Rac-type GTPase, converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho, suppressing leading-edge protrusion and promoting cell retraction to achieve cellular polarity. Suppresses RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with actin stress fiber disruption and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is vascular cell-specific, involved in modulation of angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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