Thermo Fisher Scientific Gpr161 Monoclonal Antibody (1A8)

Thermo Fisher Scientific Gpr161 Monoclonal Antibody (1A8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer.

It is the key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. It is recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, which leads to PKA-dependent processing of GLI3 into GLI3R and represses the Shh signaling.

In presence of SHH, it is removed from primary cilia and internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling.

Target Information

Upon ligand binding, G protein-coupled receptors such as GPR161 activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.