Thermo Fisher Scientific ABCA4 Polyclonal Antibody
ABCA4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot과 IHC에 적합합니다. 인간 시료 반응성이 있으며, 합성 펩타이드(aa 2230-2273)를 면역원으로 사용했습니다. 동결건조 형태로 제공되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 2230–2273 of human ABCA4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCA4.
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans.
It belongs to the ATP-binding cassette transporter gene sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene maps to chromosome 1p21–p13 and is expressed exclusively in retinal photoreceptor cells, mediating transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses show ABCR presence in foveal and peripheral cone, as well as rod photoreceptors.
Loss of central vision in Stargardt macular dystrophy patients is associated with ABCR-mediated foveal cone degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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