Thermo Fisher Scientific ABCA4 Polyclonal Antibody
ABCA4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용하였으며, 인간 시료에 반응합니다. 동결건조 상태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1450–1500 of human ABCA4 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C and avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCA4.
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It belongs to the ATP-binding cassette transporter sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene is mapped to chromosome 1p21–p13 and is expressed exclusively in retina photoreceptor cells, mediating transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses show ABCR presence in foveal and peripheral cone, as well as rod photoreceptors. Loss of ABCR function is linked to foveal cone degeneration observed in Stargardt macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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