Thermo Fisher Scientific ABCA4 Polyclonal Antibody
ABCA4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC에 사용 가능하며, 인간 시료에 반응. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 망막 광수용체 세포 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 350–400 of human ABCA4 conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCA4.
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It is a member of the ATP-binding cassette transporter sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene is mapped to chromosomal region 1p21–p13 and is expressed exclusively in retina photoreceptor cells, mediating transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses show ABCR presence in foveal and peripheral cone, as well as rod photoreceptors.
Loss of ABCR function is associated with Stargardt macular dystrophy, leading to foveal cone degeneration and central vision loss.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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