Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI15B5), TrueMAB
인간 PDCD1(PD-1/CD279)을 인식하는 Mouse IgG2a 단일클론 항체로, Flow Cytometry에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15B5 |
| Immunogen | Full length human recombinant protein of human PDCD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which bind to ligands PDL-1 and PDL-2 to downregulate immune activation.
In PD-1 deficient mice, hyperactivated immune systems and autoimmune disorders are observed.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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