Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI13E9), TrueMAB
Cardiac Troponin I(TNNI3)을 인식하는 Mouse Monoclonal Antibody로, Western Blot에 최적화됨. HEK293T 세포에서 생산된 full-length human recombinant protein을 면역원으로 사용. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 연구용 전용 시약.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13E9 |
| Immunogen | Full length human recombinant protein of human TNNI3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Cardiac Troponin I (TNNI3) is a key inhibitory protein in cardiac muscle, forming a complex with troponin C (TnC) and troponin T (TnT).
It binds to actin within thin filaments, and calcium binding to TnC releases the inhibitory region of TnI, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels serves as a diagnostic indicator for heart muscle damage, differentiating between angina and myocardial infarction.
Mutations in the TNNI3 gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
For Research Use Only.
Not for use in diagnostic procedures or for resale without authorization.
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