Thermo Fisher Scientific Fra1 Polyclonal Antibody
Human FRA1/Fosl1 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot, ICC/IF, IP, ChIP 등 다양한 응용에 적합. 보존제 무첨가로 청정도 높으며, 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:1,500–1:50,000 | – |
| Immunoprecipitation (IP) | 0.1–0.5 µL/mg of lysate | – |
| ChIP assay (ChIP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of the Human Fosl1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788408 |
Product Specific Information
- This product is preservative-free.
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
- This antibody has specificity for Human FRA1/Fosl1.
Target Information
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1, and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes.
Unlike c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Selected ATF/CREB family members can also form leucine zipper dimers with Fos and Jun, and different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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