Thermo Fisher Scientific NAPE PLD Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NAPEPLD. Recombinant protein control fragment (Product #RP-92784). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NAPE PLD,uniProtId:Q6IQ20-1,ncbiNodeId:9606,antigenRange:317-391,antigenLength:393,antigenImageFileName:PA5-54092_NAPE_PLD_Q6IQ20-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54092_NAPE_PLD_Q6IQ20-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644465

Product Specific Information

Immunogen sequence: MKYQHVDPEE AVRIHTDVQT KKSMAIHWGT FALANEHYLE PPVKLNEALE RYGLNAEDFF VLKHGESRYL NNDDE

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.

Target Information

N-Acylphosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D (NAPE-PLD) is a membrane-bound enzyme which releases the endocannabinoid anandamide and other bioactive N-acylethanolamines from their corresponding NAPEs in animal tissues. NAPE-PLD has been shown to be expressed by specific populations of neurons in the brain and targeted to axonal processes. Recent studies have suggested that NAEs generated by NAPE-PLD in axons may act as anterograde synaptic signaling molecules that regulate the activity of postsynaptic neurons. NAPE-PLD has also been shown to catalyze the hydrolysis of NAPE to generate OEA (oleoylethanolamide), a natural lipid amide that inhibits food intake in free-feeding rodents by prolonging latency to feed and postmeal interval.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.