Thermo Fisher Scientific PHIP Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PHIP protein. Suitable for IHC(P) and ICC/IF applications. Affinity purified and supplied in PBS with glycerol and sodium azide. Recommended for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested concentration: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PHIP. Recombinant protein control fragment (Product #RP-92476). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645505 |
Product Specific Information
Immunogen sequence:
TEQPSTSSAA KTFITKANAS AIPGKTILEN SVKHSKALNT LSSPGQSSFS HGTRNNSAKE NMEKEKPVKR KMKSSVLPKA STLSKSSA
Sequence identity:
- Mouse: 75%
- Rat: 81%
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein containing eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (cytosol and nucleus) and primary beta cells (nucleus), acting as a transcriptional activator. PHIP interacts with insulin receptor substrate (IRS) family proteins, which mediate insulin receptor signaling and are critical for beta cell proliferation and survival. PHIP associates with the PH domain of IRS-1 and may link IRS-1 to insulin receptors, suggesting a key role in insulin signaling regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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