Thermo Fisher Scientific ICAM1 Monoclonal Antibody (OTI2H4), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of five extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail. It has seven potential N-linked glycosylation sites and shares sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds to integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for Rhinovirus.
It is expressed by activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils. Expression increases upon inflammation and is also found in certain carcinoma and melanoma cells.
Soluble ICAM-1 is detectable in plasma and elevated in various inflammatory conditions.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.