Thermo Fisher Scientific PDGF beta (PDGFB) Monoclonal Antibody (PDGFB, 3071)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF).
The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize or heterodimerize with PDGF subunit A.
These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in various developmental processes.
Mutations in this gene are associated with meningioma.
Reciprocal translocations between chromosomes 22 and 17, involving this gene and collagen type 1 alpha 1, are linked to dermatofibrosarcoma protuberans, a rare skin tumor.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.