Thermo Fisher Scientific ATF5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ATF5.

Target Information

ATF5 is a protein coding gene. It acts as a transcription factor that can stimulate or repress gene transcription through binding to various DNA regulatory elements such as:

• cAMP response element (CRE)
• ATF5-specific response element (ARE)
• Amino acid response element (AARE)

ATF5 is critically involved in cell survival, proliferation, and differentiation, often in a cell-type-dependent manner. It plays an important role in:

• Cerebral cortex formation and neuroprogenitor cell regulation
• Cerebellar granule neuron progenitor cell proliferation
• Survival of mature olfactory sensory neurons
• Osteogenic differentiation
• Regulation of BCL2 and EGR1 expression for anti-apoptotic function
• Cooperation with NR1I3/CAR in CYP2B6 transcriptional activation in liver
• Negative regulation of IL1B signaling pathway
• Promotion of adipocyte differentiation via CEBPB activation
• Regulation of centrosome dynamics and centriole interactions

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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