Thermo Fisher Scientific CNOT7 Polyclonal Antibody
Human 및 Mouse에 반응하는 Rabbit Polyclonal CNOT7 항체로, WB 및 ICC/IF에 사용 가능. 합성 펩타이드로부터 유래된 면역원 사용. 액상 형태로 1 mg/mL 농도, PBS 버퍼 및 50% glycerol 포함. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CNOT7 (Accession Q9UIV1), corresponding to amino acid residues E243–S285 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850709 |
Product Specific Information
Antibody detects endogenous levels of total CNOT7.
Target Information
CNOT7 (CCR4-NOT transcription complex subunit 7) has 3′–5′ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8.
CNOT7 is a catalytic component of the CCR4-NOT complex, a major cellular mRNA deadenylase linked to various processes including:
- Bulk mRNA degradation
- miRNA-mediated repression
- Translational repression during initiation
- General transcription regulation
During miRNA-mediated repression, the complex acts as a transcriptional repressor during translational initiation.
CNOT7 associates with BTG family members such as TOB1 and BTG2 and is required for their anti-proliferative activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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