Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Tyr72) Monoclonal Antibody (EM-26)

Applications

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

This antibody recognizes phosphorylated intracellular tyrosine 72 of CD3 zeta chain (CD247), a component of the TCR/CD3 complex expressed on T cells.
Western Blot: non-reducing conditions recommended.

Target Information

The CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating cell surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 subunits (gamma, delta, epsilon, zeta), which are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
The CD3 components have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif.
CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation.
CD3 antigen is present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Decreased T lymphocyte percentages may be observed in certain autoimmune diseases.
Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency due to CD3delta/CD3epsilon/CD3zeta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.