Thermo Fisher Scientific MEPCE Monoclonal Antibody (OTI1H10)
MEPCE 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. Human 및 Mouse 시료에 반응하며, 동결건조 형태로 제공됩니다. 재구성 후 1 mg/mL 농도로 사용 가능하며, 연구용으로 적합합니다.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–289 of human MEPCE (NP_062552) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MEPCE is an S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5′-end of 7SK snRNA, stabilizing it. It also functions non-enzymatically as part of the 7SK RNP complex, which regulates transcription elongation by sequestering P-TEFb and promoting snRNA gene transcription through interaction with the little elongation complex (LEC). Within the 7SK RNP complex, MEPCE stabilizes 7SK RNA and facilitates complex assembly. Interaction with LARP7 occludes its catalytic center, supporting its structural role. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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