Thermo Fisher Scientific Diazepam Binding Inhibitor (DBI) Monoclonal Antibody (OTI3A10)
인간 DBI 단백질(아미노산 2-104)을 인식하는 단클론 항체. Western blot에 1:500 희석으로 사용 가능. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 호르몬 조절 및 지질 대사 관련 연구에 적합.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–104 of human DBI (NP_065438) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The diazepam binding inhibitor (DBI) is a hormone-regulated protein involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines that modulate signal transduction at type A GABA receptors in brain synapses.
It is conserved from yeast to mammals, with a highly conserved hydrophobic binding domain for medium- and long-chain acyl-CoA esters.
DBI also mediates feedback regulation of pancreatic secretion and postprandial cholecystokinin release, and participates in corticotropin-dependent adrenal steroidogenesis.
Three pseudogenes have been identified on chromosomes 6, 8, and 16. Multiple transcript variants encoding different isoforms exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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