Thermo Fisher Scientific EDG3 Polyclonal Antibody
인간 EDG3/S1P3 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 6 µg/mL로 검증됨. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공. PBS buffer와 0.1% sodium azide 포함, 장기 보관 시 -20°C 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal extracellular domain of human EDG3 / S1P3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550873 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gibbon, Monkey: 93%
- Gorilla, Marmoset: 87%
- Rabbit: 80%
Target Information
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG-3 is sphingosine-1-phosphate.
There are 8 known members of the EDG receptor family, implicated in mediating growth-related effects such as:
- Induction of cellular proliferation
- Alterations in differentiation and survival
- Suppression of apoptosis
They also evoke cellular effector functions dependent on cytoskeletal responses such as:
- Contraction
- Secretion
- Adhesion
- Chemotaxis
EDG receptors are developmentally regulated and differ in tissue distribution.
They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases.
EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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