Thermo Fisher Scientific MMP2 Recombinant Rabbit Monoclonal Antibody (SI15-04)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select optimal candidates for production.

Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the large rabbit immune repertoire

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix. They share a conserved activation mechanism and metal-binding active site region, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play essential roles in angiogenesis regulation.

MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. The MMP family includes at least eighteen secreted and membrane-bound zinc endopeptidases that collectively degrade fibrillar and non-fibrillar collagens, fibronectin, laminin, and basement membrane glycoproteins.

Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.