Thermo Fisher Scientific MMP9 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody does not cross-react with other MMP family members.

Target Information

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase belonging to a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins.
MMP9 is secreted as a 92 kDa zymogen, and cleavage of pro-MMP9 results in the active enzyme (82 kDa). It has a gelatin-binding domain with three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain, and a hemopexin-like domain.

MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells. It plays roles in:

• Inflammatory responses
• Tissue remodeling
• Wound healing
• Tumor growth and metastasis

MMP9, derived from bone marrow cells, contributes to skin carcinogenesis and degrades type IV and V collagens.
Studies suggest involvement in IL-8-induced mobilization of hematopoietic progenitor cells and tumor-associated tissue remodeling. Elevated MMP9 levels are associated with progression of idiopathic atrial fibrillation and aortic aneurysm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.