Thermo Fisher Scientific MMP9 Polyclonal Antibody
Rat 시료에 반응하는 MMP9 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합. E. coli 발현 rat 92-kDa collagenase를 면역원으로 사용. 단백질 A로 정제된 액상 항체이며, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunoprecipitation (IP) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-expressed active rat 92-kDa type IV collagenase (catalytic domain) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2235384 |
Product Specific Information
This antibody does not cross-react with other MMP family members.
Target Information
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase belonging to a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins.
MMP9 is secreted as a 92 kDa zymogen, and cleavage of pro-MMP9 results in the active enzyme (82 kDa). It has a gelatin-binding domain with three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain, and a hemopexin-like domain.
MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells. It plays roles in:
- Inflammatory responses
- Tissue remodeling
- Wound healing
- Tumor growth and metastasis
MMP9, derived from bone marrow cells, contributes to skin carcinogenesis and degrades type IV and V collagens.
Studies suggest involvement in IL-8-induced mobilization of hematopoietic progenitor cells and tumor-associated tissue remodeling. Elevated MMP9 levels are associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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