Thermo Fisher Scientific CD357 (AITR/GITR) Monoclonal Antibody (eBioAITR), APC, eBioscience
인간 AITR/GITR 단백질을 인식하는 eBioAITR 클론 단일클론 항체로, APC 형광 표지되어 있습니다. Flow Cytometry에 최적화된 사용 농도(5 µL/test)로 제공되며, 고순도 친화 크로마토그래피 정제. 면역조절 관련 연구용으로 적합합니다.
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Thermo Fisher Scientific CD357 (AITR/GITR) Monoclonal Antibody (eBioAITR), APC, eBioscience
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): Not tested
View 1 publication - Flow Cytometry (Flow): 5 µL (1 µg)/test
View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioAITR |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573235 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- APC-eFluor 780
- eFluor 450
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Custom conjugation available
Product Specific Information
The monoclonal antibody reacts with human AITR (Activation Inducible TNFR family member), an approximately 25 kDa member of the TNFR superfamily.
AITR mRNA is detected in lymph node, peripheral blood leukocytes, and weakly in spleen. Expression is upregulated within 24 hours upon PMA/ionomycin or PHA stimulation of PBMCs. At the protein level, AITR is expressed by a small population of activated PBMCs.
AITR associates with TRAF1, TRAF2, and TRAF3 and induces NF-κB activation via TRAF2. TL6 (AITRL) has been reported as the ligand for AITR, important for cross-talk between T lymphocytes and endothelial cells.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated for flow cytometry of normal human peripheral blood cells.
Use at 5 µL (1 µg) per test (final volume 100 µL). Cell number range: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene (mapped to 1p36.33).
This receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance maintained by CD25⁺CD4⁺ regulatory T cells.
Knockout studies in mice indicate involvement in CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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