Thermo Fisher Scientific CD100 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: YNCYKGYLPR QCLKFRSALL IGKKKPKSDF CDREQSLKET LVEPGSFSQQ NGEHPKPALD TGYETEQDTI TSKVPTDRED SQRIDDLSAR DKPFDVKCEL KFADSDADGD
• Positive Samples: 293T
• Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40–CD40L B cell signaling by augmenting B cell aggregation and survival and downregulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.