Thermo Fisher Scientific CD100 Polyclonal Antibody
Human CD100(SEMA4D)를 인식하는 Rabbit Polyclonal Antibody로, WB와 ELISA에 사용 가능. 액상 형태이며 Affinity Chromatography로 정제됨. PBS/glycerol buffer에 보존되며 -20°C에서 보관. 세포막 단백질 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 753–862 of human SEMA4D (NP_0063693) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.79 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804332 |
Product Specific Information
- Immunogen sequence: YNCYKGYLPR QCLKFRSALL IGKKKPKSDF CDREQSLKET LVEPGSFSQQ NGEHPKPALD TGYETEQDTI TSKVPTDRED SQRIDDLSAR DKPFDVKCEL KFADSDADGD
- Positive Samples: 293T
- Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40–CD40L B cell signaling by augmenting B cell aggregation and survival and downregulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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