Thermo Fisher Scientific NALCN Monoclonal Antibody (N187/7)
NALCN 단백질 검출용 Mouse monoclonal antibody (Clone N187/7). Western blot 및 Immunocytochemistry에 적합. Human, Mouse, Rat 반응성. Protein G 정제, PBS/glycerol buffer, -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific NALCN Monoclonal Antibody (N187/7)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N187/7 |
| Immunogen | Fusion protein amino acids 1659–1738 (cytoplasmic C-terminus) of rat NALCN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735285 |
Additional Formats
Product Specific Information
- 1 µg/mL of MA5-27593 was sufficient for detection of NALCN in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 200 kDa.
- This antibody was formerly sold as clone S187-7.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to sodium, potassium, and calcium ions. It regulates resting membrane potential and neuronal excitability. Nalcn activity is modulated by neuropeptides such as neurotensin and substance P via SRC family kinases-dependent pathways. It is required for normal respiratory rhythm, neonatal survival, and systemic osmoregulation by controlling serum sodium concentration. Nalcn is involved in intestinal pace-making activity and modulation of substantia nigra pars reticulata neuron excitability.
Diseases associated with NALCN include congenital contractures of limbs and face, hypotonia, developmental delay, and infantile psychomotor retardation with characteristic facies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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