Thermo Fisher Scientific SHANK3 Monoclonal Antibody (S69)
SHANK3 단백질을 특이적으로 인식하는 Mouse IgG2b 단클론 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며, 단백질 G 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific SHANK3 Monoclonal Antibody (S69)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-Dependent |
| Antibody Microarray (AM) | Assay-Dependent |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S69 |
| Immunogen | Synthetic peptide amino acids 840–857 of rat Shank3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735363 |
Available Conjugated Formats
Product Specific Information
1 µg/mL of MA5-27601 was sufficient for detection of Shank3 in 10 µg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 190 kDa. No cross-reactivity against Shank1 or Shank2.
Target Information
SHANK3 is a major scaffold postsynaptic density protein that interacts with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance. It interconnects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, via complexes with GKAP/PSD-95 and HOMER, and the actin-based cytoskeleton.
SHANK3 plays a role in structural and functional organization of dendritic spines and synaptic junctions through interaction with Arp2/3 and WAVE1 complexes, promoting F-actin clusters and regulating actin dynamics. It participates in developing neuron growth cone motility and NMDA receptor signaling, modulates GRIA1 exocytosis and GRM5/MGLUR5 signaling, and controls AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity.
SHANK3 may be required at early stages of synapse formation and inhibited by IGF1 to promote synapse maturation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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