Thermo Fisher Scientific IL-15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Publications: References

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total IL15.

Target Information

IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer cell activation and proliferation.
IL-15 and IL-2 share many biological activities as both bind common hematopoietin receptor subunits and may compete for the same receptor, negatively regulating each other’s activity.
CD8+ memory cell numbers are controlled by the balance between IL-15 and IL-2.
IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6.
In mouse studies, IL-15 may increase expression of apoptosis inhibitor Bcl-xL through STAT6 activation, preventing apoptosis.
IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, as well as activation of intracellular signaling molecules.
It is essential for immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases.
Neutralization of IL-15 shows beneficial effects in models of psoriasis and diabetes.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.