Thermo Fisher Scientific IL5RA (soluble) Polyclonal Antibody
IL5RA 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 마우스 반응성, 고순도 친화 크로마토그래피 정제, PBS/glycerol 저장 버퍼 구성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL5RA (Accession Q01344), corresponding to amino acid residues T161–L211 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899384 |
Product Specific Information
Antibody detects endogenous levels of total IL5RA.
Target Information
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation.
IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), composed of two chains:
- Alpha chain: binds IL-5 with low affinity
- Beta chain: does not bind IL-5 directly, but together with alpha chain forms the high-affinity IL-5 receptor
The cytoplasmic domains of both chains are essential for signal transduction.
The membrane-proximal proline-rich sequence of the IL-5Rα cytoplasmic domain is critical for IL-5-induced proliferation, nuclear proto-oncogene expression, and tyrosine phosphorylation of proteins such as JAK1 and JAK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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