Thermo Fisher Scientific ETS1 Polyclonal Antibody
ETS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 시료에 반응하며 높은 특이성과 순도를 가진 액상 형태 제품입니다. 항원 친화 크로마토그래피로 정제되어 안정적인 신호 검출을 제공합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ETS1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.36 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735771 |
Product Specific Information
- Positive Control: Jurkat, Jurkat nuclear extract
- Predicted Reactivity: Rat (100%), Rabbit (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein belonging to the DNA-binding ETS family.
It is a multifunctional protein with:
- N-terminal pointed domain
- Central transactivation domain
- Two auto-inhibitory domains flanked by conserved C-terminal Ets domain
ETS1 interacts with PEBP2alphaA, p300/CBP, and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression increases in resting T-cells.
Activity is modulated by AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies, while EAP1/Daxx interaction represses MMP1 and BCL2 transactivation.
ETS1 also interacts with STAT6 to modulate Socs-1 expression induced by IL-4 and with GATA3 to positively regulate Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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