Thermo Fisher Scientific Human ARMER Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human ARMER.
PEP-0180 can be used as a blocking peptide with polyclonal antibody PA5-20061.

Target Information

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA.
Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress.

Recently, ARMER, a novel integral ER-membrane protein, was shown to protect cells from ER stress-induced apoptosis.
Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown.

It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.