Thermo Fisher Scientific Human ARMER Synthetic Peptide
Human ARMER 단백질의 N-말단 15개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 차단 실험에 활용 가능하며, 인간 세포에서 ER 스트레스 관련 아폽토시스 연구에 적합. 고순도 정제, 액상 형태로 제공.
- 카탈로그번호
- PEP0180
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human ARMER.
PEP-0180 can be used as a blocking peptide with polyclonal antibody PA5-20061.
Target Information
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA.
Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress.
Recently, ARMER, a novel integral ER-membrane protein, was shown to protect cells from ER stress-induced apoptosis.
Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown.
It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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