Thermo Fisher Scientific SNAIL Polyclonal Antibody
SNAIL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 종양 침윤 및 EMT 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human SNAIL (aa 1–49) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913202 |
Product Specific Information
- Positive Control: Human kidney tissue, SiHa, K562, HUVEC, LOVO, human tonsil tissue, human liver cancer tissue, mouse testis tissue
- Subcellular Location: Nucleus, Cytoplasm
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm, contributing to mesoderm and neural crest formation. SNAI1 plays a key role in tumor invasion through E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, SNAI1 and/or SNAI2 (Slug) expression are linked to E-cadherin repression, metastasis, recurrence, and poor prognosis. Snail 1 protein in the stroma may serve as a putative prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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