Thermo Fisher Scientific LRRTM2 Polyclonal Antibody
LRRTM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. WB 및 IHC에 사용 가능하며, 인간, 마우스, 랫트 반응성이 있습니다. 액상 형태로 제공되며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the carboxy terminus of human LRRTM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153649 |
Product Specific Information
- Suggested positive control: SK-N-SH cell lysate
- PA5-21097 can be used with blocking peptide PEP-1211
Target Information
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and mediate presynaptic and postsynaptic glutamatergic differentiation. LRRTM1 and LRRTM2 are most potent at inducing presynaptic differentiation.
Each LRRTM protein is a type I transmembrane protein containing ten extracellular leucine-rich repeats and a short intracellular tail, with a distinct developmental expression pattern.
LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. It also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, which plays a critical role in excitatory synapse development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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