Thermo Fisher Scientific AXIN2 Polyclonal Antibody
AXIN2 단백질을 표적하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 또는 -20°C 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide near the carboxy terminus of human AXIN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156428 |
Product Specific Information
- A suggested positive control is mouse lung tissue lysate.
- PA5-21093 can be used with blocking peptide PEP-1207.
Target Information
The Axin-related protein, Axin2, plays an important role in regulating β-catenin stability in the Wnt signaling pathway. In mouse, conductin (homolog of Axin2) forms a multiprotein complex with APC, β-catenin, and GSK3β, leading to β-catenin degradation. Deregulation of β-catenin is implicated in various malignancies.
The AXIN2 gene is located at 17q23–q24, a region frequently showing loss of heterozygosity in cancers such as breast cancer and neuroblastoma. Mutations in this gene are associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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