Thermo Fisher Scientific SOS1 Polyclonal Antibody
Human SOS1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot과 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1.58 mg/mL 농도의 액상 형태. 세포 신호전달 연구 및 Ras 활성화 경로 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human SOS1. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.58 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736647 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2
- Predicted Reactivity: Mouse (100%), Rat (100%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog consist of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region.
Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras, activating the MAPK cascade central to cellular proliferation, survival, and differentiation. Growth factor stimulation induces phosphorylation of Sos on multiple serine and threonine sites, and phosphorylation within the Sos C-terminus by MAP/ERK kinase disrupts the Grb2-Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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