Thermo Fisher Scientific PKR Recombinant Rabbit Monoclonal Antibody (SC06-37)
PKR 단백질 검출을 위한 Recombinant Rabbit Monoclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, HEK293 발현 시스템에서 생산된 단일 클론 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC06-37 |
| Immunogen | Synthetic peptide within human PKR (aa 500–540) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898918 |
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. PKR plays a key role in antiviral defense mediated through its activation by double-stranded RNA produced during viral infection. It is involved in IFN-induced innate antiviral responses, virus-induced apoptosis, and regulation of cell growth and differentiation.
PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling. Upon viral infection, PKR acts as a dual regulator of both cell survival and death pathways through kinase-dependent and -independent mechanisms. It modulates multiple pathways, including NF-kappaB activation, p53, p38, and PDGF signaling. PKR has been implicated in tumor suppression and malignancy, as well as in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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