Thermo Fisher Scientific ATP2C2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ATP2C2 protein. Validated for Western blot at 1:1,000–1:3,000 dilution. Supplied as liquid, 1 mg/mL in PBS with 50% glycerol. Detects endogenous ATP2C2 involved in calcium transport. For research use only.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATP2C2 (Accession O75185), corresponding to amino acid residues D505–L555 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853018 |
Product Specific Information
Antibody detects endogenous levels of total ATP2C2.
Target Information
ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting distinct physiological roles.
Unlike ATP2C1, ATP2C2 shows a restricted expression pattern, higher maximal turnover rate for Ca²⁺-ATPase reaction, and lower affinity for cytosolic Ca²⁺ activation. Overexpression in mammary tumors induces Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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