Thermo Fisher Scientific SPARC/Osteonectin Monoclonal Antibody (OSTN/3759)
SPARC/Osteonectin 단백질을 인식하는 Mouse Monoclonal Antibody로, Human 시료에 반응. WB, IHC, Peptide Array에 사용 가능. 200 µg/mL 농도의 액상 형태이며, Protein A/G로 정제. 세포외기질 및 골형성 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OSTN/3759 |
| Immunogen | Recombinant fragment (around aa1–200) of human SPARC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody stability: 24 months
- Positive Control: Human placenta, lymph node or spleen; JEG3 or A549 cell lysates
- Cellular Localization: Secreted; Basement membrane
Specificity Comments:
SPARC (Secreted Protein Acidic and Rich in Cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein secreted by endothelial cells. It is identical to osteonectin, a protein important for bone calcification and conserved across species. SPARC regulates endothelial barrier function through F-actin-dependent changes in cell shape, forming intercellular gaps that allow macromolecule extravasation.
Target Information
The SPARC gene encodes a cysteine-rich acidic matrix-associated protein essential for bone collagen calcification and extracellular matrix synthesis. It influences cell shape and has been linked to both tumor suppression and metastasis. Three transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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